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Anabolic-androgenic steroids cycle administration decreases anxious-like behavior but does not affect long-term memory acquisition in rats Biological Sciences
Oliveira, Luís Flávio Souza de; Staudt, Miriam; Machado, Michel Mansur; Fuentefria, Alexandre Meneghello.
The steroid hormones are lipids in nature, which play crucial roles in several metabolic and behavioral pathways in mammals. Drug therapy uses sterol hormones for treating some disturbances linked with its deficiency; however, the illicit use of these hormones by amateur and elite athletes to enhance performance or body appearance may lead to several health issues. In this study we evaluated the anxious-like behavior and the long-term memory acquisition of male rats undergoing sedentary life-style or physical effort, with or without anabolic-androgenic steroids (ASC) treatment. The results showed a decrease in anxious-like behavioral levels in rats that received ASC treatment associated or not with physical effort, but this treatment did not affect the...
Tipo: Info:eu-repo/semantics/article Palavras-chave: 2.10.00.00-0 androgens; Physical exercise; Memory; Anxiety Farmacologia de esteroides androgênicos.
Ano: 2019 URL: http://periodicos.uem.br/ojs/index.php/ActaSciBiolSci/article/view/45014
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Cd, Cu, and Mn from Uruguay River Basin in Uruguaiana, RS, Brazil, and their toxicological potential for human leukocyte Biological Sciences
Costa, Gislaine Rezer; Rocha, Mariana Balhego; Querol, Marcus Vinicius Morini; Dal Magro, Jacir; Machado, Michel Mansur; Oliveira, Luís Flávio Souza de.
This study assessed the limnology from the Medium Uruguay River Basin in Uruguaiana, Brazil, with a focus on the concentration of heavy metals (Cd, Cu, and Mn), to assess the toxicological potential (cytotoxicity and genotoxicity) for humans using as biological matrix of study human leukocyte cells. The conductivity, resistivity, and dissolved O2 levels exceeded the limits recommended by the National Environmental Council (Conselho Nacional do Meio Ambiente - CONAMA). The percentage of non-viable human leukocyte cells exposed to water samples was approximately 20% higher than that of the negative control (<3%), but similar to the positive control. The DNA damage index was high for all heavy metal concentrations assayed when compared to the negative...
Tipo: Info:eu-repo/semantics/article Palavras-chave: 2.00.00.00-6 ecotoxicology; Genotoxicity; Limnology; Heavy metals; Uruguay River Basin Ecotoxicologia.
Ano: 2016 URL: http://periodicos.uem.br/ojs/index.php/ActaSciBiolSci/article/view/31998
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Evaluation of the tickcide, genotoxic, and mutagenic effects of the Ruta graveolens L. (Rutaceae) Biological Sciences
Carvalho, Alessandra Vargas de; Lübeck, Irina; Rocha, Mariana Balhego da; Güez, Camila Martins; Machado, Michel Mansur; Oliveira, Luís Flávio Souza de.
Current analysis investigated the tickcide effects of the aqueous extract and chloroform fractions of Ruta graveolens L. (rue) on engorged females of Rhipicephalus microplus, as well as their genotoxic and mutagenic effects on human leukocytes. The best tickcide activity (non-dependent dose) and genotoxic / mutagenic effects (dependent-dose) were observed on exposure to chloroform fractions. Results suggest that extract fractions of R. graveolens L are efficient against R. microplus, although the fraction and the tested concentrations show genotoxic and mutagenic potential for human leukocytes. 
Tipo: Info:eu-repo/semantics/article Palavras-chave: 2.10.07.00-4 acaricide; Genotoxicity; Rue. Toxicologia e Etnofarmacologia.
Ano: 2015 URL: http://periodicos.uem.br/ojs/index.php/ActaSciBiolSci/article/view/27576
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